急性期精神分裂症患者WCST执行功能与PANSS五因子分的相关性研究(1)
[摘要]目的 探討急性期精神分裂症患者威斯康星卡片分类测验(WCST)执行功能与PANSS五因子分的相关性。方法 选取2017年5～11月在我院住院的急性期精神分裂症患者，计划纳入患者200例。对纳入患者的相关人口统计学资料及疾病资料进行统计，如年龄、发病年龄、病程、受教育年限等；于患者治疗第1周末使用WCST评定患者的执行功能，对总测验次数、正确反应数、持续错误数、随机错误数和完成分类数等数据进行统计；于患者治疗第1周末使用阳性与阴性症状量表(PANSS)对急性期患者的精神症状进行评定，对PANSS的30个项目进行主成分分析，其中9项组成阴性因子，7项组成认知因子，4项组成阳性因子，4项组成兴奋因子，6项组成焦虑抑郁因子，计算各项因子的得分。结果 不同受教育年限、不同发病年龄、不同PANSS阴阳得分患者的WCST执行功能评分比较，差异均有统计学意义(P<0.05)；患者的受教育年限与总测验次数、持续错误数、随机错误数成负相关(r=-0.01、-0.23、-0.18)，与正确反应数、完成分类数成正相关(r=0.35、0.37)；发病年龄与持续错误数、随机错误数成负相关(r=-0.14、-0.35)，与总测验次数、正确反应数、完成分类数成正相关(r=0.31、0.17、0.14)；PANSS阳性得分与总测验次数、持续错误数、随机错误数成负相关(r=-0.09、-0.05、-0.08)，与正确反应数、完成分类数成正相关(r=0.17、0.15)；PANSS阴性得分与正确反应数、完成分类数成负相关(r=-0.13、-0.36)与总测验次数、持续错误数、随机错误数成正相关(r=0.35、0.26、0.25)。Pearson相关性分析显示，患者WCST执行功能的正确反应数、完成分类数与PANSS中阴性症状评分成负相关，持续错误数、随机错误数与阴性症状评分成正相关，其他项均无显著相关性。结论 急性期精神分裂症患者存在WCST执行功能缺陷，其与患者的阴性症状存在一定的相关性。对急性期精神分裂症患者执行功能的研究将更有助于患者的诊断、疾病预测、预后判断、治疗及康复。
[关键词]精神分裂症患者；WCST执行功能；PANSS五因子分；相关性研究
[中图分类号] R749.3 [文献标识码] A [文章编号] 1674-4721(2018)9(c)-0011-05
Correlation study between WCST executive function and five factor score of PANSS in patients with schizophrenia at acute stage
XIAO Jian-wen HUANG Li SHEN Ying
Department of Psychiatry， the Third People′s Hospital of Ganzhou City， Jiangxi Province， Ganzhou 341000， China
[Abstract] Objective To explore the correlation between Wisconsin card classification test (WCST) executive function and five factor score of PANSS in patients with schizophrenia at acute stage. Methods Patients with schizophrenia at acute stage hospitalized in our hospital from May to November 2017 were selected and 200 patients were included in the plan. The relevant demographic data and disease data in patients included were counted， such as age， age of onset， course of disease， length of education， etc. WCST was used to assess the executive function of the patients at the end of the first week of treatment. Total test times， correct response number， persistent error number， random error number and completing classification number were counted. At the end of the first week of treatment， positive and negative symptom scale (PANSS) was used to assess the psychiatric symptoms of patients in acute stage. Principal component analysis was performed on 30 items of PANSS， among them， 9 items forming negative factors， 7 items forming cognitive factors， 4 items forming positive factors， 4 items forming excitatory factors and 6 items forming anxiety and depression factors. The score of various factor was calculated respectively. Results WCST executive function scores of patients with different educational years， different age of onset and different negative and positive scores of PANSS were statistically significant (P<0.05). The educational years of the patients was negatively correlated with the total tests number， persistent error number and random error number (r=-0.01， -0.23， -0.18) respectively， and the educational years of the patients was positively correlated with correct response number， completing classification number (r=0.35， 0.37) respectively. The age of onset was negatively correlated with persistent error number and random error number (r=-0.14， -0.35) respectively， and the age of onset was positively correlated with total test times， correct response number， completing classification number (r=0.31， 0.17， 0.14) respectively. The positive score of PANSS was negatively correlated with total test times， persistent error number and random error number (r=-0.09， -0.05， -0.08) respectively， and the positive score of PANSS was positively correlated with correct response number， completing classification number (r=0.17， 0.15) respectively. The negative scoer of PANSS was negatively correlated with correct response number， completing classification number (r=-0.13， -0.36) respectively， and the negative score of PANSS was positively correlated with total test times， persistent error number and random error number (r=0.35， 0.26， 0.25) respectively. Pearson correlation analysis showed that the correct response number and completing classification number of WCST executive function were negatively correlated with negative symptom score of PANSS， and the persistent error number and random error number were positively correlated with negative symptom score， while the other items were not significantly correlated. Conclusion WCST executive function defect exists in patients with schizophrenia at acute stage， and it has certain correlation with negative symptoms. The study of executive function in patients with schizophrenia at acute stage will be more conducive to diagnosis， disease prediction， prognosis judgment， treatment and rehabilitation of patients., 百拇医药(肖剑文 黄丽 申璎)
[关键词]精神分裂症患者；WCST执行功能；PANSS五因子分；相关性研究
[中图分类号] R749.3 [文献标识码] A [文章编号] 1674-4721(2018)9(c)-0011-05
Correlation study between WCST executive function and five factor score of PANSS in patients with schizophrenia at acute stage
XIAO Jian-wen HUANG Li SHEN Ying
Department of Psychiatry， the Third People′s Hospital of Ganzhou City， Jiangxi Province， Ganzhou 341000， China
[Abstract] Objective To explore the correlation between Wisconsin card classification test (WCST) executive function and five factor score of PANSS in patients with schizophrenia at acute stage. Methods Patients with schizophrenia at acute stage hospitalized in our hospital from May to November 2017 were selected and 200 patients were included in the plan. The relevant demographic data and disease data in patients included were counted， such as age， age of onset， course of disease， length of education， etc. WCST was used to assess the executive function of the patients at the end of the first week of treatment. Total test times， correct response number， persistent error number， random error number and completing classification number were counted. At the end of the first week of treatment， positive and negative symptom scale (PANSS) was used to assess the psychiatric symptoms of patients in acute stage. Principal component analysis was performed on 30 items of PANSS， among them， 9 items forming negative factors， 7 items forming cognitive factors， 4 items forming positive factors， 4 items forming excitatory factors and 6 items forming anxiety and depression factors. The score of various factor was calculated respectively. Results WCST executive function scores of patients with different educational years， different age of onset and different negative and positive scores of PANSS were statistically significant (P<0.05). The educational years of the patients was negatively correlated with the total tests number， persistent error number and random error number (r=-0.01， -0.23， -0.18) respectively， and the educational years of the patients was positively correlated with correct response number， completing classification number (r=0.35， 0.37) respectively. The age of onset was negatively correlated with persistent error number and random error number (r=-0.14， -0.35) respectively， and the age of onset was positively correlated with total test times， correct response number， completing classification number (r=0.31， 0.17， 0.14) respectively. The positive score of PANSS was negatively correlated with total test times， persistent error number and random error number (r=-0.09， -0.05， -0.08) respectively， and the positive score of PANSS was positively correlated with correct response number， completing classification number (r=0.17， 0.15) respectively. The negative scoer of PANSS was negatively correlated with correct response number， completing classification number (r=-0.13， -0.36) respectively， and the negative score of PANSS was positively correlated with total test times， persistent error number and random error number (r=0.35， 0.26， 0.25) respectively. Pearson correlation analysis showed that the correct response number and completing classification number of WCST executive function were negatively correlated with negative symptom score of PANSS， and the persistent error number and random error number were positively correlated with negative symptom score， while the other items were not significantly correlated. Conclusion WCST executive function defect exists in patients with schizophrenia at acute stage， and it has certain correlation with negative symptoms. The study of executive function in patients with schizophrenia at acute stage will be more conducive to diagnosis， disease prediction， prognosis judgment， treatment and rehabilitation of patients., 百拇医药(肖剑文 黄丽 申璎)