[摘要]目的 探讨沙库巴曲缬沙坦治疗慢性心功能不全的临床效果。方法 选取我院2017年6～10月收治的30例慢性心功能不全患者作为研究对象，所有患者在常规治疗基础上加用沙库巴曲缬沙坦治疗，标准化连续治疗3个月，观察患者治疗的总有效率，比较患者治疗前后的心功能指标、血浆N末端脑钠肽(NT-proBNP)水平、生活质量。结果 治疗后，显效15例，有效13例，无效2例，总有效率为93.33%。治疗后，患者的LVEF、FS及KCCQ量表评分均显著高于治疗前，NT-proBNP水平显著低于治疗前，差异有统计学意义(P<0.01)。不良反应发生率为10.00%。结论 沙库巴曲缬沙坦治疗慢性心功能不全可明显改善患者的心功能，降低其NT-proBNP水平，安全可靠，可显著提高其生活质量，值得临床推广。

    [关键词]沙库巴曲缬沙坦；慢性心功能不全；心功能；生活质量

    [中图分类号] R541.6 [文献标识码] A [文章编号] 1674-4721(2018)7(a)-0051-03

    [Abstract]Objective To investigate the clinical effect of Sacubitril/valsartan treating chronic cardiac insufficiency.Methods A total of 30 cases with chronic cardiac insufficiency treated in our hospital from June to October 2017 were selected as the research subjects.All patients were treated by Sacubitril/valsartan on the basis of the conventional therapy.Standardized continuous treatment lasted for 3 months.The total effective rate for treatment of the patients was observed.The cardiac function indexes ......