不同蓝光照射方式治疗新生儿黄疸的临床效果(1)
[摘要]目的 综合分析不同蓝光照射方式治疗新生儿黄疸的临床效果。方法 选取 2014年12月～ 2016年12月我院收治的108例黄疸患儿，按照不同的蓝光照射方式随机数字表法将其分为实验组、对照组，每组 54例。分析两组患儿的临床疗效、不良反应发生率及对肝功能(总胆红素、丙氨酸氨基转移酶以及碱性磷酸酶)、细胞因子(C反应蛋白、转铁蛋白)水平的影响。结果 实验组患儿临床治疗总有效率显著高于对照组，差异有统计学意义(P<0.05)；治疗前，两组患儿的肝功能和细胞因子水平比较，差异无统计学意义(P>0.05)；治疗后，实验组患儿的肝功能和细胞因子水平显著优于对照组，差异有统计学意义(P<0.05)；实验组患儿不良反应发生率显著低于对照组，差异有统计学意义(P<0.05)。结论 间歇蓝光照射方法在新生儿黄疸中的疗效显著优于持续蓝光照射方法。
[关键词]不同蓝光照射方式；新生儿黄疸；疗效；肝功能；细胞因子水平
[中图分类号] R722 [文献标识码] A [文章编号] 1674-4721(2018)4(a)-0105-03
Clinical effect of different blue light irradiation methods in the treatment of neonatal jaundice
GUO Qun-xi LI Li
Department of Neonatology，Luoding Maternal and Child Health，Guangdong Province，Luoding 527200，China
[Abstract]Objective To comprehensive analyze the clinical effects of different blue light irradiation methods in the treatment of neonatal jaundice.Methods A total of 108 cases of jaundice in children were selected from December 2014 to December 2016 treated in our hospital，and divided into experimental group and control group according to the random number table method of different blue light irradiation，54 cases in each group.The clinical efficacy，incidence of adverse reactions and effects on liver function(total bilirubin，alanine aminotransferase and alkaline phosphatase)，cytokine(C-reactive Protein，transferrin) were analyzed.Results The total effective rate of the experimental group was significantly higher than that of the control group，the difference was statistically significant(P<0.05). Before treatment，there was no significant difference in liver function and cytokine levels between the two groups(P>0.05).After treatment，the level of liver function and cytokine in the experimental group was significantly higher than that in the control group，the difference was statistically significant(P<0.05).The incidence of adverse reactions in the experimental group was significantly lower than that in the control group，the difference was statistically significant(P<0.05).Conclusion The efficacy of intermittent blue light irradiation in the treatment of neonatal jaundice is significantly better than that of the continuous blue light irradiation.
[Key words]Different blue light irradiation；Neonatal jaundice； Efficacy；Liver function；Levels of cytokines
新生兒黄疸是新生儿常见的临床疾病之一，严重时会引起胆红素脑病[1-2]。新生儿黄疸主要包括以下几种症状：生理性黄疸、母乳性黄疸以及病理性黄疸。新生儿黄疸的胆红素代谢力比较差，体内积累了大量的胆红素会造成皮肤黄染和其他器官黄染等。由于新生儿的胃肠道和肝酶系统发育不够完善，加上胆红素无法快速代谢，所以会直接影响到黄疸新生儿的智力发育状况，最终引起严重的后遗症[3-4]。笔者将根据相关工作经验，综合分析不同蓝光照射方式在新生儿黄疸中的疗效及对肝功能、细胞因子水平的影响，为治疗黄疸患儿提供科学的数据参考。现报道如下。, http://www.100md.com(郭群喜 黎丽)
[关键词]不同蓝光照射方式；新生儿黄疸；疗效；肝功能；细胞因子水平
[中图分类号] R722 [文献标识码] A [文章编号] 1674-4721(2018)4(a)-0105-03
Clinical effect of different blue light irradiation methods in the treatment of neonatal jaundice
GUO Qun-xi LI Li
Department of Neonatology，Luoding Maternal and Child Health，Guangdong Province，Luoding 527200，China
[Abstract]Objective To comprehensive analyze the clinical effects of different blue light irradiation methods in the treatment of neonatal jaundice.Methods A total of 108 cases of jaundice in children were selected from December 2014 to December 2016 treated in our hospital，and divided into experimental group and control group according to the random number table method of different blue light irradiation，54 cases in each group.The clinical efficacy，incidence of adverse reactions and effects on liver function(total bilirubin，alanine aminotransferase and alkaline phosphatase)，cytokine(C-reactive Protein，transferrin) were analyzed.Results The total effective rate of the experimental group was significantly higher than that of the control group，the difference was statistically significant(P<0.05). Before treatment，there was no significant difference in liver function and cytokine levels between the two groups(P>0.05).After treatment，the level of liver function and cytokine in the experimental group was significantly higher than that in the control group，the difference was statistically significant(P<0.05).The incidence of adverse reactions in the experimental group was significantly lower than that in the control group，the difference was statistically significant(P<0.05).Conclusion The efficacy of intermittent blue light irradiation in the treatment of neonatal jaundice is significantly better than that of the continuous blue light irradiation.
[Key words]Different blue light irradiation；Neonatal jaundice； Efficacy；Liver function；Levels of cytokines
新生兒黄疸是新生儿常见的临床疾病之一，严重时会引起胆红素脑病[1-2]。新生儿黄疸主要包括以下几种症状：生理性黄疸、母乳性黄疸以及病理性黄疸。新生儿黄疸的胆红素代谢力比较差，体内积累了大量的胆红素会造成皮肤黄染和其他器官黄染等。由于新生儿的胃肠道和肝酶系统发育不够完善，加上胆红素无法快速代谢，所以会直接影响到黄疸新生儿的智力发育状况，最终引起严重的后遗症[3-4]。笔者将根据相关工作经验，综合分析不同蓝光照射方式在新生儿黄疸中的疗效及对肝功能、细胞因子水平的影响，为治疗黄疸患儿提供科学的数据参考。现报道如下。, http://www.100md.com(郭群喜 黎丽)