多沙唑嗪缓释片改善输尿管支架管相关症状的非随机—对照研究(1)
[摘要] 目的 探讨多沙唑嗪缓释片改善输尿管支架管相关症状的效果。 方法 将2014年3～9月我院58例泌尿系结石术后留置输尿管支架管的患者分为试验组和对照组，试验组24例，对照组34例。对照组术后1～3 d拔除尿管，口服抗生素预防感染，术后2～4周拔除输尿管支架管；试验组在对照组基础上，口服甲磺酸多沙唑嗪缓释片4 mg，1次/d，2～4周。拔管前独立完成国际前列腺症状评分(IPSS)、生活质量评估(QOL)、视觉模拟量表评分(VAS)评分问卷。 结果 试验组IPSS评分与对照组比较，差异有统计学意义[(9.12±0.99)分 vs (11.65±1.39)分，t=7.616，P=0.000]；QOL评分与对照组比较，差异有统计学意义[(2.21±0.59)分 vs (2.68±0.84)分，t=2.345，P=0.023]；VAS评分与对照组比较，差异有统计学意义[(1.54±0.59)分 vs (1.97±0.67)分，t=2.514，P=0.015]；血尿发生率与对照组比较，差异无统计学意义(37.50% vs 44.12%，χ2=0.254，P=0.614)。 结论 多沙唑嗪控释片可改善输尿管支架管相关症状以及患者的生活质量。
[关键词] 多沙唑嗪缓释片；支架管相关症状；泌尿系结石
[中图分类号] R697.3 [文献标识码] A [文章编号] 1674-4721(2016)05(a)-0148-03
Non randomized controlled study on Doxazosin Sustained Release Tablets in improving associated symptoms of urethral stent
ZHANG Nan KONG Su-fang GE Lei GUO Liang MA Yao-hui QU Xiao-wei SHAN Zhong-jie
Department of Urology Surgery，Zhengzhou People′s Hospital，Zhengzhou 450003，China
[Abstract] Objective To discuss the effect of Doxazosin Sustained Release Tablets in improving associated symptoms of urethral stent. Methods 58 patients with urethral stent after operations due to urinary calculus treated in our hospital from March to September 2014 were selected and divided into study group (n=24) and control group (n=34).For patients in the control group，catheters were removed after 1-3 days of operation，antibiotics were orally administrated for infection prevention，and urethral stents were removed after 2-4 weeks of operation.Patients in the study group were additionally orally given Doxazosin Mesylate Sustained Release Tablets 4 mg，qd，for 2-4 weeks.IPSS，QOL，and VAS scales were accomplished separately before removing the stents. Results There were significant differences in IPSS scores，QOL scores and VAS scores [(9.12±0.99) scores vs (11.65±1.39) scores，t=7.616，P=0.000；(2.21±0.59) scores vs (2.68±0.84) scores，t=2.345，P=0.023；(1.54±0.59) scores vs (1.97±0.67) scores，t=2.514，P=0.015] between the study group and the control group.There was no significant difference in incidence of hematuria (37.50% vs 44.12%，χ2=0.254，P=0.614). Conclusion Doxazosin Sustained Release Tablets can relieve associated symptoms of urethral stent and improve living quality of patients.
[Key words] Doxazosin Sustained Release Tablets；Associated symptoms of urethral stent；Urinary calculus
1978年Finney[1]首次将双J管应用于临床，至今已有将近40年，其在减少输尿管狭窄、尿漏，促进输尿管愈合、结石排出等方面发挥了重要的作用，但是术后由于输尿管支架管的存在，往往有尿频、尿急、尿痛等下尿路症状，甚至出现肉眼血尿、腰痛等不适，导致患者的生活质量出现不同程度的下降。近年来，支架管相关症状逐步受到大家的重视[2-4]，国外文献报道，α-受体阻滞剂，如阿夫唑嗪、特拉唑嗪和坦索罗辛等对输尿管支架管相关症状有缓解作用[5]。但是，有关多沙唑嗪控释片对输尿管支架管相关症状的作用研究较少。本文通过非随机-对照研究表明，多沙唑嗪控释片可以改善输尿管支架管相关症状及提高患者的生活质量，具体报道如下。, 百拇医药(张楠 孔素芳 葛雷 郭亮 马曜辉 曲晓伟 单中杰)
[关键词] 多沙唑嗪缓释片；支架管相关症状；泌尿系结石
[中图分类号] R697.3 [文献标识码] A [文章编号] 1674-4721(2016)05(a)-0148-03
Non randomized controlled study on Doxazosin Sustained Release Tablets in improving associated symptoms of urethral stent
ZHANG Nan KONG Su-fang GE Lei GUO Liang MA Yao-hui QU Xiao-wei SHAN Zhong-jie
Department of Urology Surgery，Zhengzhou People′s Hospital，Zhengzhou 450003，China
[Abstract] Objective To discuss the effect of Doxazosin Sustained Release Tablets in improving associated symptoms of urethral stent. Methods 58 patients with urethral stent after operations due to urinary calculus treated in our hospital from March to September 2014 were selected and divided into study group (n=24) and control group (n=34).For patients in the control group，catheters were removed after 1-3 days of operation，antibiotics were orally administrated for infection prevention，and urethral stents were removed after 2-4 weeks of operation.Patients in the study group were additionally orally given Doxazosin Mesylate Sustained Release Tablets 4 mg，qd，for 2-4 weeks.IPSS，QOL，and VAS scales were accomplished separately before removing the stents. Results There were significant differences in IPSS scores，QOL scores and VAS scores [(9.12±0.99) scores vs (11.65±1.39) scores，t=7.616，P=0.000；(2.21±0.59) scores vs (2.68±0.84) scores，t=2.345，P=0.023；(1.54±0.59) scores vs (1.97±0.67) scores，t=2.514，P=0.015] between the study group and the control group.There was no significant difference in incidence of hematuria (37.50% vs 44.12%，χ2=0.254，P=0.614). Conclusion Doxazosin Sustained Release Tablets can relieve associated symptoms of urethral stent and improve living quality of patients.
[Key words] Doxazosin Sustained Release Tablets；Associated symptoms of urethral stent；Urinary calculus
1978年Finney[1]首次将双J管应用于临床，至今已有将近40年，其在减少输尿管狭窄、尿漏，促进输尿管愈合、结石排出等方面发挥了重要的作用，但是术后由于输尿管支架管的存在，往往有尿频、尿急、尿痛等下尿路症状，甚至出现肉眼血尿、腰痛等不适，导致患者的生活质量出现不同程度的下降。近年来，支架管相关症状逐步受到大家的重视[2-4]，国外文献报道，α-受体阻滞剂，如阿夫唑嗪、特拉唑嗪和坦索罗辛等对输尿管支架管相关症状有缓解作用[5]。但是，有关多沙唑嗪控释片对输尿管支架管相关症状的作用研究较少。本文通过非随机-对照研究表明，多沙唑嗪控释片可以改善输尿管支架管相关症状及提高患者的生活质量，具体报道如下。, 百拇医药(张楠 孔素芳 葛雷 郭亮 马曜辉 曲晓伟 单中杰)